News Pressroom

October 18, 2001

MedImmune Reports Results for First Nine Months of 2001

Nine Month Highlights

  • Revenues reach $326 million
  • Net earnings increase 59 percent to $50 million
  • Sales of Synagis® grow 24 percent; new outcomes data show broader use
  • Acquisition of U.S. rights to Ethyol® completed
  • Nine clinical trials initiated and enrollment in ten trials completed
  • FDA approval of Enhanced Yield Process for Synagis granted in August

Gaithersburg, MD, October 18, 2001 -- MedImmune, Inc. (Nasdaq: MEDI) today announced that net earnings for the first nine months of 2001 increased 59 percent to $50 million, or $0.23 per diluted share, on total revenues of $326 million. Net earnings for the first nine months of 2000 were $32 million, or $0.14 per diluted share, on total revenues of $302 million. Product sales for the 2001 nine-month period grew to $304 million from $268 million in the 2000 period, primarily due to growth of Synagis (palivizumab). Sales of Synagis to wholesalers and distributors during the 2001 nine-month period grew 24 percent to $267 million ($241 million in the U.S.) from $215 million ($198 million in the U.S.) for the same period in 2000.

"We continue to make excellent progress in building our business," stated David M. Mott, MedImmune's chief executive officer. "We completed the reacquisition of Ethyol rights in the U.S. and the expansion of our oncology business unit ahead of schedule. Effective October 1, we began recording 100 percent of sales rather than the thirty-five percent transfer price we previously recorded on shipments to ALZA. The national launch meeting for Ethyol and our new oncology sales force will take place next week.

"We are entering this year's RSV season in a strong position with the Pediatric Specialty Sales force, which we hired last year, now fully trained and established in the field," continued Mott. "Recent data from our outcomes registry leads us to believe the long-term market potential for Synagis may be greater than we had previously anticipated. Finally, we have been making substantial progress in research and development. During the first nine months of 2001: we initiated nine new clinical studies and completed enrollment in ten; presented clinical data on siplizumab at two international psoriasis meetings; received FDA's approval to produce Synagis with our proprietary Enhanced Yield Process that quadruples fermentation yields; and made tremendous progress with our preclinical anti-asthma IL-9 program."

Additional Results for Nine Months Ended September 30, 2001

Gross margins for the first nine months of 2001 improved to 75 percent from 73 percent for the comparable 2000 period due to a change in product mix and improved manufacturing efficiencies for Synagis. Selling, general and administrative costs increased to $128 million in the 2001 period from $98 million in 2000 due primarily to costs associated with the reacquisition of U.S. rights to Ethyol in the third quarter, and an increase in sales support for Synagis. Total research and development costs increased to $62 million in the 2001 period from $49 million in the 2000 period due to a larger number of active clinical trials. Other operating expenses increased to $8 million in the first nine months of 2001 from $6 million in 2000.

Results for the Quarter Ended September 30, 2001

As previously announced on September 10, 2001, MedImmune's results for the third quarter were substantially impacted by the reacquisition of U.S. rights to Ethyol from ALZA Corporation. Total revenues for the 2001 quarter were $47 million compared to $62 million for the 2000 third quarter. Product sales for the 2001 quarter decreased to $40 million from $47 million in the 2000 quarter due primarily to a charge to revenues for the reacquisition of ALZA's unsold Ethyol inventory at September 30, 2001, coupled with a cessation of supply sales to ALZA for the quarter. Sales of Synagis in the 2001 third quarter were modest as projected, since prophylaxis for respiratory syncytial virus (RSV) disease, for which Synagis is used, does not typically commence in the Northern Hemisphere until September or October. In the 2001 third quarter, wholesalers and distributors began preparing for the upcoming RSV season as MedImmune's sales of Synagis to them totaled $30 million ($22 million in the U.S.) consistent with the 2000 third quarter when sales to wholesalers and distributors were $32 million ($22 million in the U.S.). Resales of Synagis by wholesalers and distributors to end-users during the 2001 third quarter are estimated to have grown 61 percent to $21 million ($18 million in the U.S.) from an estimated $13 million ($11 million in the U.S.) for the 2000 third quarter.

For the 2001 third quarter, MedImmune recorded a net loss of $19 million, or $0.09 per diluted share, compared to net earnings of $8 million, or $0.04 per diluted share, in the 2000 third quarter. Gross margins in the 2001 third quarter were 59 percent compared to 67 percent for the 2000 quarter due to Ethyol charges and product mix. Selling, general and administrative costs grew to $44 million for the 2001 quarter, including approximately $15 million in costs associated with the reacquisition and relaunch of Ethyol in the United States. In the 2000 third quarter, selling, general and administrative costs were $24 million. As a result of a greater number of active research, development and clinical programs, research and development expenses increased to $21 million in the 2001 quarter from $15 million in the 2000 quarter. Other operating expenses decreased to $2 million in the 2001 quarter compared to $3 million in the 2000 quarter.

Looking Ahead in 2001

The following forward-looking information is being provided as a convenience to investors. Investors should note that sales of Synagis occur primarily during the fourth and first quarters when RSV is most prevalent in the community. Results for the second and third quarters will reflect this seasonality. These projections are based upon numerous assumptions, which MedImmune cannot control and which may not develop as MedImmune expects. Consequently, actual results may differ materially from the projections made here. Please refer to the Disclosure Notice below.

For the quarter ending December 31, 2001:

  • Diluted earnings per share are projected to be $0.45 to $0.46
  • Total revenues are projected to range from $275 to $290 million
  • Gross margins are projected to improve modestly from 2000
  • R&D expenses are projected to increase approximately 25 percent over 2000
  • SG&A expenses are projected to decrease modestly from 2000 as a percent of total revenues
  • Tax rate is projected to be approximately 33 percent

For the 2001-2002 RSV season, worldwide end-user sales of Synagis are projected to increase to $590 to $610 million.

Webcast

MedImmune is offering a live webcast of a discussion by MedImmune management of its earnings and other business results on Thursday, October 18, 2001 at 5:15 p.m. EDT. The live webcast may be accessed on MedImmune's website at www.medimmune.com. A replay of the webcast will also be available via our website until October 25, 2001. An audio replay of the webcast will be available beginning at 8:15 p.m. EDT on October 18, 2001 until midnight October 25, 2001 by calling (719) 457-0820. The passcode for the audio replay is 784670.

Synagis® (palivizumab) is marketed for the prevention of serious lower respiratory tract disease caused by respiratory syncytial virus in pediatric patients at high risk of RSV disease, which is prominent in the Northern Hemisphere from October through May (see full prescribing information at www.medimmune.com). Ethyol® is marketed for the reduction of both cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer or non-small cell lung cancer ("NSCLC") and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer, where the radiation port includes a substantial portion of the parotid (see full prescribing information at www.medimmune.com).

MedImmune, Inc. is a fully integrated biotechnology company focused on developing and marketing products that address medical needs in areas such as infectious disease, immune regulation and cancer. Headquartered in Gaithersburg, Maryland, MedImmune has manufacturing facilities in Frederick, Maryland and Nijmegen, the Netherlands. For more information on MedImmune, visit the company's website at www.medimmune.com.

DISCLOSURE NOTICE: The information contained in this document is as of October 18, 2001, and will not be updated as a result of new information or future events. This document contains forward - looking statements regarding MedImmune's future financial performance and business prospects. Those statements involve substantial risks and uncertainties. You can identify those statements by the fact that they contain words such as "anticipate," "believe," "estimate," "expect," "intend," "project" or other terms of similar meaning. Those statements reflect management's current beliefs and are based on numerous assumptions which MedImmune cannot control and which may not develop as MedImmune expects. Consequently, actual results may differ materially from those projected in the forward - looking statements. Among the factors that could cause actual results to differ materially are: seasonal demand for and continued supply of our principal product; availability of competitive products in the market; availability of third-party reimbursement for the cost of our products; effectiveness and safety of our products; exposure to product liability and other types of lawsuits; foreign currency exchange rate fluctuations; changes in generally accepted accounting principles; growth in costs and expenses; the impact of acquisitions, divestitures and other unusual items; and the risks, uncertainties and other matters discussed in MedImmune's Annual Report on Form 10-K for the year ended December 31, 2000 and in its periodic reports on Forms 10-Q and 8-K (if any) filed with the U.S. Securities and Exchange Commission. MedImmune cautions that RSV disease occurs primarily during the winter months; MedImmune believes its operating results will reflect that seasonality for the foreseeable future. MedImmune sells Synagis to wholesalers and distributors. MedImmune compiles and reports estimated amounts of resales of Synagis by those wholesalers and distributors to their end-user customers (primarily hospitals and pediatricians) based on unit resale data supplied to MedImmune by its wholesalers and distributors, multiplied by MedImmune's quarterly average selling price of Synagis. MedImmune is also developing several products for potential future marketing. There can be no assurance that such development efforts will succeed, that such products will receive required regulatory clearance or that, even if such regulatory clearance were received, such products would ultimately achieve commercial success.

2001 Q2 Condensed Statements of Operations & Condensed Balance Sheets