Anti-CMET MAb

CMET is a receptor tyrosine kinase found at high levels in certain cancer cells where it is believed to be associated with tumor growth, survival and metastasis. Over-expression of cMET and its ligand, hepatocyte growth factor (HGF), has been observed in head and neck, non-small cell lung, ovarian, breast, esophageal and colorectal cancers. Preclinical research has also linked high levels of cMET to shorter overall survival times based on samples from breast and esophageal cancer patients.