MedImmune has the expertise to address target diseases
with a wide variety of vaccine technologies. We are instrumental in the
discovery and development of these cutting-edge biologics.
Live attenuated vaccine
MedImmune has developed a prudent and comprehensive strategy to apply its
unique live attenuated influenza vaccine (LAIV) technology to the development
of pandemic vaccines, prioritizing the subtypes based on current epidemiology.
Seasonal LAIV attributes suggest that a pandemic LAIV formulation may be an
important component of pandemic preparedness for both industrialized nations
and developing countries.
Reverse genetics is a method by which viruses such as influenza can be
generated from segments of DNA. Reverse genetics can be particularly useful in
the development of pandemic vaccines because the process does not require
manufacturers to work directly with potentially highly infectious strains such
as H5N1, rather only with segments of the virus's genome. Reverse genetics is
also being applied in the development of seasonal influenza vaccines.
Viral vectored vaccines
Advances in molecular virology have facilitated an understanding of the
regulation of viral replication, gene expression and molecular pathogenesis. At
the same time, this understanding has enabled the development of novel viral
vectors useful for vaccination. A variety of such vectors are now being
advanced in preclinical and clinical studies.
Virus-like particles (VLPs) consist of viral
protein(s) derived from the structural proteins of a virus. In some
cases these proteins are embedded within a lipid bilayer. These particles
resemble the virus from which they were derived, but lack viral nucleic acid,
meaning that they are not infectious. The VLPs used as vaccines are often very
effective at eliciting both T-cell and B-cell immune responses. The human
papillomavirus and hepatitis B vaccines are the first VLP-based vaccines
approved by the FDA.
Subunit vaccines contain purified antigens rather than whole organisms. These
vaccines are not infectious, so they can be given to immunosuppressed people,
and they are less likely to induce unfavorable immune reactions that may cause