MedImmune and UC San Francisco Enter Respiratory, Inflammation and Autoimmunity Disease-Focused Research Collaboration

Top scientists partner to research the progression and biology of RIA diseases

San Francisco, CA /Gaithersburg, MD

January 12, 2016 – MedImmune, the global biologics research and development arm of AstraZeneca, and the University of California, San Francisco (UCSF) today announced a research collaboration that will be focused in Respiratory, Inflammation and Autoimmunity (RIA) with an emphasis on basic research and translational sciences. The collaboration builds on the existing partnership between the two organizations formed in 2014 and leverages MedImmune’s local presence in Mountain View, CA.

Scientists from both organizations will partner to explore the disease biology and the core underlying mechanisms that drive areas of unmet medical need in RIA, such as the microbiome and regenerative medicine. The work will include extensive profiling of patient samples to expand understanding of disease progression; to identify novel biomarkers; and, to create a quantative framework to understand the effect of these biomarkers on clinical trial outcomes.

“This partnership brings together the complementary strengths of UCSF and MedImmune and will foster closer engagement between both groups,” said June Lee, MD, Director, Early Translational Research and the Catalyst Program at UCSF, who is overseeing the partnership.  “Ultimately, these collaborations will accelerate research to better understand diseases with limited treatment options, and will hopefully have significant impact.”

This partnership will include seven initial research projects over the next three years, with the potential for more projects to be included in the future. These projects will focus on idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), scleroderma, sarcoidosis, severe asthma and inflammatory bowel disease (IBD).

“We look forward to extending our existing partnership with world-renowned scientists at UCSF, an institution committed to advancing translational research,” said Dr. Bing Yao, Senior Vice President and Head of MedImmune’s Respiratory, Inflammation and Autoimmunity Innovative Medicines Unit. “Combined with MedImmune’s innovative, cutting-edge science in respiratory, inflammation and autoimmunity as well as translational medicine, we are optimistic our collective findings will benefit the patients who are most in need.”

There are significant gaps in the understanding of how these diseases progress and whether distinct patient subtypes are more amenable to current or experimental therapies. Moreover, many of these diseases are increasing in incidence, resulting in an even greater impact on health. This extensive research program will lay the groundwork for ongoing drug discovery and development aimed at identifying new medicines for the millions of patients living with these conditions who currently lack sufficient treatment options. Developing techniques to quantify the impact of predictive biomarkers on clinical outcomes data will help further advance the ultimate aim of precision medicine in these disease areas.

Details on the 2014 collaboration between MedImmune and UCSF can be found here.

About University of California, San Francisco (UCSF)
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy, a graduate division with nationally renowned programs in basic biomedical, translational and population sciences, and a preeminent biomedical research enterprise. It also includes UCSF Health, which is composed of two .two top-tier hospitals, UCSF Medical Center and UCSF Benioff Children’s Hospital San Francisco, as well as other partner and affiliated hospitals and healthcare providers throughout the Bay Area. Please visit www.ucsf.edu.

About MedImmune
MedImmune is the global biologics research and development arm of AstraZeneca, a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines. MedImmune is pioneering innovative research and exploring novel pathways across key therapeutic areas, including respiratory, inflammation and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines. The MedImmune headquarters is located in Gaithersburg, Md., one of AstraZeneca’s three global R&D centers, with additional sites in Cambridge, UK and Mountain View, CA. For more information, please visit www.medimmune.com.

MEDIA CONTACTS:
Tracy Rossin, MedImmune
rossint@medimmune.com

(301) 398-1468

June Lee, MD, UCSF
june.lee@ucsf.edu

(415) 514-8514

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