Publications

Commitment to science

Science is in our cells and in our published work. This commitment is demonstrated in a consistent track record of studies that our scientists have authored and co-authored in prestigious and high-impact peer-reviewed science journals.



Respiratory, Inflammation and Autoimmunity


Targeting the interferon pathway with sifalimumab for the treatment of systemic lupus erythematosus

PUBLISHED
2017. Immunotherapy. 2017 Jan; 9(1):57-70. doi: 10.2217/imt-2016-0090.

AREA
RIA

MEDIMMUNE AUTHORS
Clinical:
Warren Greth, Translational: Gabriel Robbie, Philip Brohawn
R&D: Micki Hultquist, Bing Yao



Development of a new ARCHITECT automated periostin immunoassay

PUBLISHED
2017. Clinica Chimica Acta. 2017 Jan 1. 464:228-235. doi: 10.1016/j.cca.2016.10.020.

AREA
RIA

MEDIMMUNE AUTHORS
Translational:
Scott Manetz, Rozanne Lee, Meina Liang, Ethan Grant, Katie Streicher,
Lydia Greenlees, Koustubh Ranade
R&D: Partha Chowdhury, Reena Varkey



Structural characterisation reveals mechanism of IL-13-neutralising monoclonal antibody tralokinumab as inhibition of binding to IL-13Rα1 and IL-13Rα2

PUBLISHED
Published online 9 Dec 2016: Journal of Molecular Biology. doi:10.1016/j.jmb.2016.12.005.

AREA
RIA

MEDIMMUNE AUTHORS
R&D:
Bojana Popovic, Gareth Rees, Matthew Gardener, Lisa Vinall, Benjamin Kemp, Jennifer Spooner, Jennifer Keen, Ralph Minter, Faisal Uddin, Trevor Wilkinson, Tristan Vaughan, Richard May
AZ: Jason Breed, Gene Colice



Targeting the T helper 2 inflammatory axis in atopic dermatitis

PUBLISHED
2016. International Archives of Allergy and Immunology. Nov 16 2016; 171(2):71-80. doi: 10.1159/000451083

AREA
RIA

MEDIMMUNE AUTHORS
Translational:
Michael Howell
Clinical: Roderick McPhee



Complement C5a induces PD-L1 expression and acts in synergy with LPS through Erk1/2 and JNK signaling pathways

PUBLISHED
Published online 14 Sep 2016. Scientific Reports. Sep 2016; 6:33346. doi: 10.1038/srep33346

AREA
RIA

MEDIMMUNE AUTHORS
R&D:
 Ling-Ling An, Jacob Gorman, Geoffrey Stephens, Bonnie Swerdlow, Paul Warrener, Jessica Bonnell, Tomas Mustelin, Michael Fung, Roland Kolbeck



Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

PUBLISHED
Published online 25 Aug 2016: MAbs. doi: 10.1080/19420862.2016.1222342.

AREA
RIA

MEDIMMUNE AUTHORS
R&D:
 Reza Esfandiary, Hasige Sathish, Steven Bishop



Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF

PUBLISHED
2016 Aug. PLoS One. 2016 Aug 04; 11(8):e0159878. doi: 10.1371/journal.pone.0159878.

AREA
RIA

MEDIMMUNE AUTHORS
Translational:
 Ethan Grant



The Human Vaccines Project: A roadmap for cancer vaccine development

PUBLISHED
2016. Science Translational Medicine. 2016: 8(361):360ra137. doi: 10.1126/scitranslmed.aag0367.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Tamer Mahmoud, Jingya Wang, Jodi Karnell, Shu Wang, Brian Naiman, Phillip Gross, Laura Carter, Tomas Mustelin, Roland Kolbeck, Ronald Herbst, Rachel Ettinger

Translational: Philip Brohawn, Chris Morehouse, Jordan Aoyama



Leishmania uses Mincle to target an inhibitory ITAM signaling pathway in dendritic cells that dampens adaptive immunity to infection

PUBLISHED
2016. Immunity. 2016: 45(4):788-801. doi: 10.1016/j.immuni.2016.09.012.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Benjamin Kemp, Matthew Robinson



Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF

PUBLISHED
2016 Aug. PLoS One. 2016 Aug 04; 11(8):e0159878. doi: 10.1371/journal.pone.0159878.

AREA
RIA

MEDIMMUNE AUTHORS
Translational: Ethan Grant



Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

PUBLISHED
Published online 25 Aug 2016: MAbs. doi: 10.1080/19420862.2016.1222342.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Reza Esfandiary, Hasige Sathish, Steven Bishop



Loss of immune tolerance is contolled by ICOS in Sle1 mice

PUBLISHED
2016 Jul. Journal of Immunology. 2016 Jul 15; 197(2):491-503. doi: 10.4049/jimmunol.1502241

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Nanette Mittereder, Ellen Kuta, Geetha Bhat, Karma Dacosta, Lily Cheng, Ronald Herbst, Gianluca Carlesso



Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study

PUBLISHED
Jun 2016. Arthritis Research & Therapy. 2016 Jun; 18(1): 131. doi: 10.1186/s13075-016-1021-2.

AREA
RIA

MEDIMMUNE AUTHORS
Clinical: Armando Flor, Daniel Cimbora, Kaushik Patra, Wenliang Yao, Barbara White, Eliezer Katz, Jorn Drappa, Sarah Sweeny
R&D:
Ronald Herbst
Translational:
Jing Li, Katie Streicher, Kathleen McKeever



Role of IgE in autoimmunity

PUBLISHED
Jun 2016. The Journal of Allergy and Clinical Immunology. 2016 Jun; 137(6): 1651-1661. doi: 10.1016/j.jaci.2016.04.007.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Miguel Sanjuan, Divya Sagar, Roland Kolbeck



Role of IgE in autoimmunity

PUBLISHED
Jun 2016. The Journal of Allergy and Clinical Immunology. 2016 Jun; 137(6): 1651-1661. doi: 10.1016/j.jaci.2016.04.007.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Miguel Sanjuan, Divya Sagar, Roland Kolbeck



Role of IgE in autoimmunity

PUBLISHED
Jun 2016. The Journal of Allergy and Clinical Immunology. 2016 Jun; 137(6): 1651-1661. doi: 10.1016/j.jaci.2016.04.007.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Miguel Sanjuan, Divya Sagar, Roland Kolbeck



Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

PUBLISHED
Jul 2016. MAbs. 2016 Jul; 8(5): 941-950. doi: 10.1080/19420862.2016.1171444.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: James Geoghegan, Ryan Fleming, Melissa Damschroder, Steven Bishop, Hasige Sathish, Reza Esfandiary



Type I IFNs regulate inflammation, vasculopathy, and fibrosis in chronic cutaneous graft-versus-host disease

PUBLISHED
Jul 2016. Journal of Immunology. 2016 Jul; 197(1): 42-50. doi: http:10.4049/jimmunol.1502190.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Tracy Delaney, Christopher Groves, Miguel Sanjuan Translational: Chris Morehouse, P. Zachary Brohawn



A sputum proteomic signature that associates with increased IL-1β levels and bacterial exacerbations of COPD

PUBLISHED
June 2016. Lung. 2016 Jun; 194(3): 363-369. doi: 10.1007/s00408-016-9877-0.

AREA
RIA

MEDIMMUNE AUTHORS
Translational: Gautam Damera, Tuyet-Hang Pham, Jianchun Zhang, Christine Ward, Paul Newbold, Koustubh Ranade



Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

PUBLISHED
Published online 25 Apr 2016: Nature Immunology. doi: 10.1038/ni.3443.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Jonathan Silver, Jennifer Kearley, Alan Copenhaver, Aaron Berlin, Roland Kolbeck, Alison Humbles; Translational: Li Yu



IL-1 is a critical regulator of group 2 Innate lymphoid cell function and plasticity

PUBLISHED
Published online 25 Apr 2016: Nature Immunology. doi: 10.1038/ni.3447.

AREA
RIA

MEDIMMUNE AUTHORS
R&D: Yoichiro Ohne, Jonathan Silver, Alan Copenhaver, Alison Humbles, Yong-Jun Liu



Sifalimumab, an anti-interferon-alpha monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

PUBLISHED
Published online 23 Mar 2016: Annals of the Rheumatic Diseases. doi: 10.1136/annrheumdis-2015-208562.

AREA
RIA

MEDIMMUNE AUTHORS
Clinical: Gabor Illei, Jorn Drappa, Liangwei Wang, Warren Greth



Self-reactive IgE exacerbates interferon responses associated with autoimmunity

PUBLISHED
Published online 21 Dec 2015: Nature Immunology. doi: 10.1038/ni.3326.

AREA
RIA

MEDIMMUNE AUTHORS
Jill Henault, Jeffrey M. Riggs, Jodi L. Karnell, Jianqing Li, Lena Shirinian, Linda Xu, Kerry A. Casey, Michael A. Smith, Deepak B. Khatry, Liat Izhak, Lorraine Clarke, Ronald Herbst, Rachel Ettinger, Tomas Mustelin, Roland Kolbeck, Miguel A. Sanjuan



A placebo-controlled study in Neuromyelitis optica – ethical and design considerations

PUBLISHED
Published online 14 Dec 2015: Multiple Sclerosis. doi: 10.1177/1352458515620934.

AREA
RIA

MEDIMMUNE AUTHORS
Kaushik Patra, Armando Flor,  Gerard Barron, John N. Ratchford, Eliezer Katz, Soraya Madani



Past, present, and future for biologic intervention in atopic dermatitis

PUBLISHED
August 2015: Allergy. 2015 Aug; 70(8):887-896. doi: 10.1111/all.12632.

AREA
RIA

MEDIMMUNE AUTHORS
M. L. Parker, Tomas Mustelin, Koustubh Ranade, Michael D. Howell



A neutralizing antibody assay based on a reporter of antibody dependent cell-mediated cytotoxicity

PUBLISHED
published online 24 Jul 2015: AAPS J. 2015  Nov;  17( 6):1417-26. doi:10.1208/s12248-015-9798-5

AREA
RIA

MEDIMMUNE AUTHORS
Hyun Jun Kim, Michael A. Bowen, Xu-Rong Jiang, Yuling Wu, Jia J. Li, Xu Liu, Weiyi Liu, Ahmad Akhgar, Susan Spitz, Lorin K. Roskos, Wendy I. White



Characterisation of stress-induced aggregate size distributions and morphological changes of a bi-specific antibody using orthogonal techniques

PUBLISHED
published online 5 June 2015: J Pharm Sci. 2015; 104(8):2473–81. doi:10.1002/jps.24530.

AREA
RIA

MEDIMMUNE AUTHORS
Katie Tingey, Malgorzata Tracka, José R. Casas-Finet, Shahid Uddin, Christopher F. van der Walle



Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

PUBLISHED
Sep 2015: Nat Commun. 2015 Sep 14; 6:8327. doi: 10.1038/ncomms9327

AREA
RIA

MEDIMMUNE AUTHORS
E. Suzanne Cohen, Ian C. Scott, Jayesh B. Majithiya, Laura Rapley, Benjamin P. Kemp, Elizabeth England, D. Gareth Rees, Catherine L. Overer-Sayers, Joanne Woods, Nicholas J. Bond, Christel Segey Veyssier, Dorothy A. Sims, Michael R. Snaith, Katherine A Vousden, Martin D. Strain, Denice T.Y. Chan, Sara Carmen, Catherine E. Huntington, Jianqing Xu, Bojana Popovic, Tristan J. Vaughan, Robin Butler, David C. Lowe, Daniel R. Higazi, Dominic J. Corkill, Richard D. May, Matthew A. Sleeman, Tomas Mustelin



Neutrophils regulate humoral autoimmunity by restricting interferon gamma production via the generation of reactive oxygen species

PUBLISHED
Aug 2015: Cell Rep. 2015 Aug 18; 12(7):1120-32. doi: 10.1016/j.celrep.2015.07.021

AREA
RIA

MEDIMMUNE AUTHORS
Zheng Liu, Philip Brohawn, Yihong Yao



Pharmacokinetics of tralokinumab in adolescents with asthma: implications for future dosing

PUBLISHED
Published online 1 Oct 2015: Br J Clin Pharmacol. doi: 10.1111/bcp.12725

AREA
RIA

MEDIMMUNE AUTHORS
Paul G. Baverel, Balaji Agoram, Meena Jain, Dewei She, Sara Sandbach



TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

PUBLISHED
Published online 13 July 2015: Nat Immunol. 2015 Sep; 16(9):970-79. doi: 10.1038/ni.3211.

AREA
RIA

MEDIMMUNE AUTHORS
Yong-Jun Liu



Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

PUBLISHED
Published online 28 Jul 2015: Lancet Respir Med. 2015 Sep 1; 3(9):692-701. doi: 10.1016/S2213-2600(15)00197-6.

AREA
RIA

MEDIMMUNE AUTHORS
Dewei She, Richard D. May, Katie Streicher, Koustubh Ranade, Edward Piper



Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection

PUBLISHED
Published online 17 Mar 2015: Immunity. 2015 Mar 17; 42(3):566-79. doi: 10.1016/j.immuni.2015.02.011.

AREA
RIA

MEDIMMUNE AUTHORS
Jennifer Kearley, Jonathan S. Silver, Aaron A. Berlin, Natalie White, Tuyet-Hang Pham, Christine K. Ward, Tomas Mustelin, Roland Kolbeck, Alison A. Humbles



Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

PUBLISHED
Published online 20 May 2015: Sci Transl Med. 2015 May 20; 7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

AREA
RIA

MEDIMMUNE AUTHORS
Tomas Mustelin



MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis

PUBLISHED
Published online 12 May 2015: Nat Commun. 2015 May 12; 6:7096. doi: 10.1038/ncomms8096.

AREA
RIA

MEDIMMUNE AUTHORS
Zheng Liu, Wei Zhu, Yue Wang, Bo Chen, Laura Richman, Yihong Yao, Ronald Herbst, Bahija Jallal



Challenges and opportunities in designing clinical trials for neuromyelitis optica

PUBLISHED
Apr 2015: Neurology. 2015 Apr 3; 84(17):1805-15. doi: 10.1212/WNL.0000000000001520.

AREA
RIA

MEDIMMUNE AUTHORS
Gerard Barron, Armando Flor



Suppression of T cell activation and collagen accumulation by an anti-type I interferon receptor monoclonal antibody with systemic sclerosis

PUBLISHED
Published online 20 May 2015: Journal of Investigative Dermatology. 2015 Oct; 135(10):2402-2409. doi: 10.1038/jid.2015.188.

AREA
RIA

MEDIMMUNE AUTHORS
Xiang Guo, Lorin Roskos, Wendy White, Brandon Higgs, Yihong Yao



Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-a in suppressing remodeling of blood vessels and lymphatics in airway inflammation

PUBLISHED
Published online 5 September 2015: American Journal of Pathology. 2015 Nov; 185(11):2949-2968. doi: 10.1016/j.ajpath.2015.07.010.

AREA
RIA

MEDIMMUNE AUTHORS
Brian Naiman, Tomas Mustelin, Jane Connor, Christopher Morehouse, Philip Browhawn


Infectious Disease


Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults

PUBLISHED
2017. Antimicrobial Agents and Chemotherapy. 2017 Jan; 61(1):e01020-16. doi: 10.1128/AAC.01020-16.

AREA
Infection

MEDIMMUNE AUTHORS
Translational: Xiang-Qing Yu, Gabriel  Robbie, Yuling Wu, Mark Esser
Clinical: Kathryn Jensen, Terramika Bellamy, Hasan Jafri



Immunotherapies against antibiotics-resistant Klebsiella pneumoniae

PUBLISHED
Published online 18 Jul 2016: Human Vaccines & Immunotherapeutics. doi: 10.1080/21645515.2016.1210746.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Xiaodong Xiao, Herren Wu, William Dall’Acqua



A novel class of small molecule agonists with preference for human over mouse TLR4 activation

PUBLISHED
2016. Plos One. 2016; 11(10):e0164632. doi: 10.1371/journal.pone.0164632.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Jason Marshall, Sean Maynard, David Hornigold, Andrey Tovchigrechko, Li Yu Translational:Darren Heeke, Eileen Rao, Jennifer Woo
AZ: Christopher McCrae, Neil Fraser, Nicola Williams, Sarah King, Martin Cooper



Analytical characterization of an oil-in-water adjuvant emulsion

PUBLISHED
Published online 14 Sep 2016: AAPS PharmSciTech. doi: 10.1208/s12249-016-0626-8.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Jenny Sun, Richard  Remmele, Gautam Sanyal



S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence facter alpha toxin

PUBLISHED
2016. Scientific Reports. 2016: 6:35466. doi: 10.1038/srep35466.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Taylor Cohen, Omari Jones-Nelson, Meghan Hotz, JoAnn Suzich, Kendall Stover, Bret Sellman
Translational: Lily Cheng



Mutations in scFv antibody fragments modulate allosteric response via hydrogen-bond network fluctuations

PUBLISHED
2016. Biophysical Journal. 2016: 110(9):1933-1942. doi: 10.1016/j.bpj.2016.03.033.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Malgorzata Tracka, Shahid Uddin, Jose Casas-Finet



IVIG-mediated protection against necrotizing pneumonia caused by MRSA

PUBLISHED
2016 Sep. Science Translational Medicine. 2016 Sep 21; 8(357):357ra124. doi: 10.1126/scitranslmed.aag1153.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Christine Tkaczyk, Bret Sellman



Analytical Characterization of an Oil-in-Water Adjuvant Emulsion

PUBLISHED
Published online 14 Sep 2016: AAPS PharmSciTech. doi: 10.1208/s12249-016-0626-8.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Jenny Sun, Richard  Remmele, Gautam Sanya



Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893

PUBLISHED
2016 Aug. Antimicrobial Agents and Chemotherapy. 2016 Aug 22; 60(9):5312-5321. doi: 10.1128/AAC.00357-16.

AREA
Infection

MEDIMMUNE AUTHORS
Translational: Yuling Wu, Mark Esser R&D: David Tabor, Li Yu, Hoyin Mok, Christine Tkaczyk, Bret Sellman, Vaheh Oganesyan,Tim Slidel, Michael McCarthy Clinical: Hasan Jafri, AZ: Patricia Bradford



The SAATELLITE and EVADE Clinical StudiesWithin the COMBACTE Consortium: A Public–Private Collaborative Effort in Designing and Performing Clinical Trials for Novel Antibacterial Drugs to Prevent Nosocomial Pneumonia

PUBLISHED
2016 Aug. Clinical Infectious Diseases. 2016 Aug 15; 63(Suppl 2): S46-S51. doi: 10.1093/cid/ciw245.

AREA
Infection

MEDIMMUNE AUTHORS
Translational: Mark Esser Clinical: Hasan Jafri Regulatory Affairs:  Brian Bishop 



Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

PUBLISHED
2016 Jul. Cell. 2016 Jul 28; 166(3):596-608. doi: 10.1016/j.cell.2016.05.073.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Nicole Kallewaard, Josephine McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, Frances Palmer-Hill, Andy Yuan, JoAnn Suzich, Qing Zhu



A novel antibody discovery platform identifies anti-influenza A broadly neutralizing antibodies from human memory B cells

PUBLISHED
Jul 2016. MAbs. 2016 Jul; 8(5): 916-927. doi: 10.1080/19420862.2016.1170263.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Xiaodong Xiao, Yan Chen, Reena Varkey, Nicole Kallewaard, Adem Koksal, Qing Zhu, Herren Wu, Partha Chowdhury, William Dall’Acqua



Targeting alpha toxin and ClfA with a multimechanistic monoclonal-antibody-based approach for prophylaxis of serious Staphylococcus aureus disease

PUBLISHED
Jun 2016. mBio. 2016 Jun; 7(3). doi: 10.1128/mBio.00528-16.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Christine Tkaczyk, Melissa Hamilton, Agnieszka Sadowska, Yue Shi, Chew-Shan Chang, Partha Chowdhury, Rebecca Buonapane, Xiaodong Xiao, Paul Warrener,  JoAnn Suzich, Ken Stover, Bret Sellman



Target-agnostic identification of functional monoclonal antibodies against Klebsiella pneumoniae multimeric MrkA fimbrial subunit

PUBLISHED
Jun 2016. Journal of Infectious Diseases. 2016 Jun; 213(11): 1800-1808. doi: 10.1093/infdis/jiw021.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Qun Wang, Chew-Shun Chang, Meghan Pennini, Mark Pelletier, Saravanan Rajan, Jingying Zha, Yan Chen, Romana Cvitkovic, Agnieszka Sadowska, Jenny Heidbrink Thompson, Hung Yu Lin, Arnita Barnes, Keith Rickert, Susan Wilson, C. Kendall Stover, William Dall’Acqua, Partha Chowdhury, Xiaodong Xiao



Development of electrochemiluminescent serology assays to measure the humoral response to antigens of respiratory syncytial virus

PUBLISHED
April 2016. PLoS One. 2016 Apr 12; 11(4): e0153019. doi: 10.1371/journal.pone.0153019.

AREA
Infection

MEDIMMUNE AUTHORS
R&D: Li Yu, Ryan Yamagata,Tansy Leonardson, Vera Chio, Samuel Park, Marcia Carlson, Shushil Machhi, Nancy Ulbrandt
Translational: Sarah Maifeld, Bodrey Ro, Hoyin Mok, Marla Chu, Bandita Parhy, Kathy Wang, Fengrong Zuo, Mark Esser



Alternatives to antibiotics

PUBLISHED
Published online 31 Mar 2016: Intensive Care Medicine. doi: 10.1007/s00134-016-4339-y.

AREA
Infection

MEDIMMUNE AUTHORS
Hasan Jafri



A phase 1a, first-in-human, randomized study of a respiratory syncytial virus F protein vaccine with and without a toll-like receptor-4 agonist and stable emulsion adjuvant

PUBLISHED
Published onine 19 Apr 2016: Vaccine. doi: 10.1016/j.vaccine.2016.04.002.

AREA
Infection

MEDIMMUNE AUTHORS
Clinical: Judith Falloon, Fei Ji, Filip Dubovsky, Therese Takas
R&D: Tonya Villafana, Translational: Mark Esser, Stacie Lambert



Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

PUBLISHED
March 9 2016. Science Translational Medicine. 2016 Mar: 8(329):329ra31 doi: 10.1126/scitranslmed.aad9922.

AREA
Infection

MEDIMMUNE AUTHORS
Taylor Cohen, Jamese Hilliard, Omari Jones-Nelson, Ashley Keller, Christine Tkaczyk, Antonio DiGiandomenico, Melissa Hamilton, Mark Pelletier, Qun Wang, JoAnn Suzich,  Kendall Stover, Bret Sellman, Terrence O’Day, Lily Cheng



Alternatives to antibiotics—a pipeline portfolio review

PUBLISHED
February 2016. The Lancet Infectious Diseases. 2016 Feb; 16(2): 239-251. doi: 10.1016/S1473-3099(15)00466-1.

AREA
Infection

MEDIMMUNE AUTHORS
Steven Projan



The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public–private partnerships for the development of new strategies to tackle antibiotic resistance

PUBLISHED
February 2016: Journal of Antimicrobial Chemotherapy. 2016 Feb; 71(2):290-295. doi: 10.1093/jac/dkv339.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Hasan S. Jafri



Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial

PUBLISHED
December 2015: The Lancet Journal of Infectious Diseases. 2015 Dec; 15(12):1398-1408. doi: 10.1016/S1473-3099(15)00247-9.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Hasan S. Jafri, M. Pamela Griffin, Terramika Bellamy, Kathryn M. Jensen, Brian S. Harris



MEDI4893* promotes survival and extends the antibiotic treatment window in a Staphylococcus aureus immunocompromised pneumonia model

PUBLISHED
August 2015: Antimicrobial Agents and Chemotherapy. 2015 Aug; 59(8):4526-4532. doi: 10.1128/AAC.00510-15.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Lei Hua, Taylor Cohen, Yue Yue Shi, Jamese J. Hilliard, Christine Tkaczak, JoAnn Suzich, C. Ken Stover, Brett R. Sellman, Victoria Datta



Characterization of a prefusion-specific antibody that recognizes a quaternary, cleavage-dependent epitope on the RSV fusion glycoprotein

PUBLISHED
Jul 2015: PLoS Pathog. 2015 Jul 11; 11(7):e1005035. doi: 10.1371/journal.ppat.1005035.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Nita K. Patel, Kari Kramer, Qing Zhu, Nancy D. Ulbrandt



Healthcare utilization and costs associated with S. aureus and P. aeruginosa pneumonia in the intensive care unit: a retrospective observational cohort study in a US claims database

PUBLISHED
Published online 21 Jun 2015: BMC Health Serv Res. 2015 Jun 21; 15:241. doi: 10.1186/s12913-015-0917-x.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Moe H. Kyaw, Hasan S. Jafri, Judith Falloon



Enhanced immunogenicity of a respiratory syncytial virus (RSV) F subunit vaccine formulated with the adjuvant GLA-SE in cynomolgus macaques

PUBLISHED
Published online 20 Jul 2015: Vaccine. 2015 Aug 26; 33(36):4472-78. doi: 10.1016/j.vaccine.2015.07.025.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Kathryn Patton, Shahin Aslam, Cindy Shambaugh, Rui Lin, Darren Heeke, Chris Frantz, Fengrong Zuo, Mark T. Esser, Xavier Paliard, Stacie L. Lambert



A novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models

PUBLISHED
Published online 20 Mar 2015: Plos One. 2015 Mar 20; 10(3):e0119509. doi: 10.1371/journal.pone.0119509.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Stacie L. Lambert, Shahin Aslam, Elizabeth Stillman, Mia MacPhail, Christine Nelson, Bodrey Ro, Rosemary Sweetwood, Yuk Man Lei, Jennifer C. Woo, Roderick S. Tang



Characterization of a prefusion-specific antibody that recognizes a quaternary, cleavage-dependent epitope on the RSV fusion glycoprotein

PUBLISHED
Published online 10 July 2015: PLoS Pathogens. 2015 Jul; 11(7):e1005035. doi: 10.1371/journal.ppat.1005035.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Nita K. Patel, Kari Kramer, Qing Zhu, Nancy D. Ulbrandt



Pseudomonas aeruginosa bacteremic patients exhibit nonprotective antibody titers against therapeutic antibody targets PcrV and Psl exopolysaccharide

PUBLISHED
Published online 02 Sep 2015: Journal of Infectious Diseases. doi: 10.1093/infdis/jiv436.

AREA
Infectious Disease

MEDIMMUNE AUTHORS
Ashley Keller, Norah J. Shire, M. Margarita Camara, Caitlin Guenther, Wei Zhao, Paul Warrener, C. Kendall Stover, Antonio DiGiandomenico


Oncology


Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery

PUBLISHED
2017. Cancer Immunology Research. 2017 Jan; 5(1):29-41. doi: 10.1158/2326-6066.CIR-16-0114.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Suzanne Mosely, John Prime, Richard Sainson, Jens-Oliver Koopmann, Rebecca Leyland, Stefanie Mullins, Luciano Pacelli, Danielle Marcus, Judith Anderton, Amanda Watkins, Jane Coates Ulrichsen, Matthew McCourt, James Harper, Michelle Morrow, Viia Valge-Archer, Ross Stewart, Simon Dovedi, Robert Wilkinson
Translational: Philip Brohawn, Brandon Higgs
AZ: Dennis Wang, Danielle Greenawalt,  Miika Ahdesmaki,  Hazel Jones



Phase II study of MEDI-575, an anti-platelet–derived growth factor-α antibody, in patients with recurrent glioblastoma

PUBLISHED
Published online 14 Nov 2016: Journal of Neuro-Oncology. doi: 10.1007/s11060-016-2287-6.

AREA
Oncology

MEDIMMUNE AUTHORS
Clinical: Paola Canelos, Shengyan Hong, Minal Nade, Kevin Laubscher
Translational: Rajesh Narwal
Patient Safety: Robert Miday



Targeting CD73 in the tumor microenvironment with MEDI9447

PUBLISHED
2016. OncoImmunology. Aug 2016; 5(8). doi: 10.1080/2162402X.2016.1208875.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Carl Hay, Erin Sult, Qihui Huang, Kathy Mulgrew, Stacy Fuhrmann, Kelly McGlinchey, Scott Hammond, Raymond Rothstein, Jonathan Rios-Doria, Edmund Poon, Nick Holoweckyj, Nicholas Durham, Melissa Damschroder, Ronald Herbst, Robert Hollingsworth, Kris Sachsenmeier
AZ: Ching Ching Leow



Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma

PUBLISHED
2016. Diagnostic Pathology. 2016: 11(1):95. doi: 10.1186/s13000-016-0545-8.

AREA
Oncology

MEDIMMUNE AUTHORS
Translational: Marlon Rebelatto, Keith Steele, Paul Robbins
Clinical:
Xia Li, Xiaoping Jin, John Blake-Haskins
AZ:
Anita Midha, Jill Walker



The Human Vaccines Project: A roadmap for cancer vaccine development

PUBLISHED
2016. Science Translational Medicine. 2016: 8(334):334ps9. doi: 10.1126/scitranslmed.aaf0685.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Scott Hammond



Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

PUBLISHED
2016 Sep. Cancer Cell. 2016 Sep 12; 30(3):391-403. doi: 10.1016/j.ccell.2016.06.025.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Erin Sult, Carl Hay, Qihui Huang , Kris Sachsenmeier 



Phase 1 dose escalation study of MEDI-565, a bispecific T-cell engager that targets human carcinoembryonic antigen (CEA), in patients with advanced gastrointestinal (GI) adenocarcinomas

PUBLISHED
Published online 4 Aug 2016: Clinical Colorectal Cancer. doi: 10.1016/j.clcc.2016.07.009.

AREA
Oncology

MEDIMMUNE AUTHORS
Clinical: Jennifer McDevitt, Jonathan Norton R&D: Song Ren Translational: Gabriel Robbie, Patricia Ryan, Serguei Soukharev, Haifeng Bao



An immunoinhibition approach to overcome the impact of pre-existing antibodies on cut point establishment for immunogenicity assessment of moxetumomab pasudotox

PUBLISHED
Aug 2016. Journal of Immunological Methods. 2016 Aug; 435: 68-76. doi: 10.1016/j.jim.2016.05.007

AREA
Oncology

MEDIMMUNE AUTHORS
Translational: Amy Schneider, Inna Vainshtein, Lorin Roskos, Carlos Chavez, Bo Sun, Meina Liang



Lipid- and polyion-based micelles as agonist platforms for TNFR superfamily receptors

PUBLISHED
July 2015. Journal of Controlled Release. 2016 Jul; 234: 104-114. doi: 10.1016/j.jconrel.2016.05.041.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Ryan Gilbreth, Shabazz Novarra, Leslie Wetzel, Stelios Florinas, Jonathan Rios-Doria, Ronald Christie, Manuel Baca



Genetic modification of oncolytic Newcastle disease virus for cancer therapy

PUBLISHED
2016 Jun. Journal of Virology. 2016 Jun; 90(11):5343-5352. doi: 10.1128/JVI.00136-16.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Xing Cheng, Weijia Wang, Qi Xu, James Harper, Danielle Carroll, Mark Galinski, JoAnn Suzich, Hong Jina



Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer

PUBLISHED
6 Jun 2016: Journal of Clinical Oncology. doi: 10.1200/JCO.2016.67.9761.

AREA
Oncology

MEDIMMUNE AUTHORS
Clinical: Xiaoping Jin, John Blake-Haskins, Ashok Gupta R&D: Marlon Rebelatto,                     AZ Authors: John Kurland



Characterization of IgG2 disulfide bonds with LC/MS/MS and postcolumn online reduction

PUBLISHED
May 2016. Analytical Chemistry. 2016 May 17; 88(10): 5080-5087. doi: 10.1021/acs.analchem.5b04368.

AREA
Oncology

MEDIMMUNE AUTHORS
Hongji Liu, Qing Lei, Michael Washabaugh



Design and synthesis of tesirine, a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload

PUBLISHED
Published online 24 May 2016: ACS Medicinal Chemistry Letters. doi: 10.1021/acsmedchemlett.6b00062.

AREA
Oncology

MEDIMMUNE AUTHORS
Arnaud Tiberghien, Jean-Noel Levy, Luke Masterson, Neki Patel, Lauren Adams, Simon Corbett, David Williams, John Hartley, Philip Howard



Design and synthesis of tesirine, a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload

PUBLISHED
Published online 24 May 2016: ACS Medicinal Chemistry Letters. doi: 10.1021/acsmedchemlett.6b00062.

AREA
Oncology

MEDIMMUNE AUTHORS
Arnaud Tiberghien, Jean-Noel Levy, Luke Masterson, Neki Patel, Lauren Adams, Simon Corbett, David Williams, John Hartley, Philip Howard



Design and synthesis of tesirine, a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload

PUBLISHED
Published online 24 May 2016: ACS Medicinal Chemistry Letters. doi: 10.1021/acsmedchemlett.6b00062.

AREA
Oncology

MEDIMMUNE AUTHORS
Arnaud Tiberghien, Jean-Noel Levy, Luke Masterson, Neki Patel, Lauren Adams, Simon Corbett, David Williams, John Hartley, Philip Howard



A potent HER3 monoclonal antibody that blocks both ligand-dependent and independent activities: differential impacts of PTEN-status on tumor response

PUBLISHED
Apr 2016. Molecular Cancer Therapeutics. 2016 Apr; 15(4): 689-701. doi: 10.1158/1535-7163.MCT-15-0555.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Zhan Xiao, Rosa Carrasco, Kevin Schifferli, Krista Kinneer, Ravinder Tammali,
Hong Chen, Ray Rothstein, Leslie Wetzel, Chunning Yang, Partha Chowdhury,
Ping Tsui, Philipp Steiner, Bahija Jallal, Ronald Herbst, Robert Hollingsworth,
David Tice



Genomic landscape survey identifies SRSF1 as a key oncodriver in small cell lung cancer

PUBLISHED
April 2016. PLoS Genetics. 2016 Apr 19; 12(4):e1005895. doi: 10.1371/journal.pgen.1005895.

AREA
Oncology

MEDIMMUNE AUTHORS
R&D: Zhan Xiao, Xin Yao,Sarah Conley, Haihong Zhong, Zheng Liu, Dong Shen, Wei Zhu, Meggan Czapiga, Vaheh Oganesyan, David Tice, Ronald Herbst, Bahija Jallal
Translational: Jiaqi Huang, Brandon Higgs, Philip Brohawn, Song Wu, Chris Morehouse, Yinong Sebastian, Katie Streicher, Yihong Yao
AZ: Haihua Fu, Xinying Su, Yi Gu



Biodistribution analyses of a near-infrared, fluorescently labeled, bispecific monoclonal antibody using optical imaging

PUBLISHED
2016. Comparative Medicine. 2016; 66(2): 90-99. doi: http://openurl.ingenta.com/content/nlm?genre=article&issn=1532-0820&volume=66&issue=2&spage=90&aulast=Peterson

AREA
Oncology

MEDIMMUNE AUTHORS
Translational: Norman Peterson, George Wilson
R&D: Qihui Huang, Nazzareno Dimasi, Kris Sachsenmeier



Integrative analyses of colorectal cancer show Immunoscore is a stronger predictor of patient survival than microsatellite instability

PUBLISHED
March 2016. Immunity. 2016 Mar; 44(3):698-711. doi: 10.1016/j.immuni.2016.02.025.

AREA
Oncology

MEDIMMUNE AUTHORS
Viia Valge-Archer (Medi R&D and AZ), Helen Angell (AZ)



Safety and antitumour activity of durvalumab plus
tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study

PUBLISHED
March 2016: The Lancet Oncology. 2016 Mar; 17(3):299-308. doi: 0.1016/S1470-2045(15)00544-6.

AREA
Oncology

MEDIMMUNE AUTHORS
Rajesh Narwal, Keith Steele, Ashok Gupta, Yu Gu, Joyson Karakunnel



The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

PUBLISHED
February 24 2016. Science Translational Medicine. 2016 Feb; 8(327):327ra26. doi: 10.1126/scitranslmed.aad6352.

AREA
Oncology

MEDIMMUNE AUTHORS
Viia Valge-Archer



A biparatopic HER2-targeting antibody-drug conjugate induces tumor regression in primary  models refractory to or ineligible for HER2-targeted therapy

PUBLISHED
January 11 2016. Cancer Cell. 2016 Jan; 29(1):117-129. doi: 10.1016/j.ccell.2015.12.008

AREA
Oncology

MEDIMMUNE AUTHORS
John Li, Samuel Perry, Vanessa Muniz-Medina, Xinzhong Wang, Leslie Wetzel, Marlon Rebelatto, Mary Jane Masson Hinrichs, Binyam Bezabeh, Ryan Fleming, Nazzareno Dimasi, Hui Feng, Dorin Toader, Andy Yuan, Lan Xu, Jia Lin, Changshou Gao, Herren Wu, Rakesh Dixit, Jane Osbourn, Steven Coats



BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data

PUBLISHED
Published online 17 Nov 2015: Nucleic Acids Research. doi: 10.1093/nar/gkv1102.

AREA
Oncology

MEDIMMUNE AUTHORS
Wei Zhu, Michael Kuziora, Todd Creasy, Christopher Morehouse, Xiang Guo, Yinong Sebastian, Dong Shen, Jiaqi Huang, Yihong Yao, Brandon W. Higgs



Development of a trispecific antibody designed to simultaneously and efficiently target three different antigens on tumor cells

PUBLISHED
September 2015: Molecular Pharmaceutics. 2015 Sep; 12(9):3490-3501.doi: 10.1021/acs.molpharmaceut.5b00268.

AREA
Oncology

MEDIMMUNE AUTHORS
Nazzareno Dimasi, Ryan Fleming, Carl Hay, Rob Woods, Linda Xu, Herren Wu, Changshou Gao



Use of MiniColumns for Isotherm Parameter Estimation and Prediction of Benchtop Column Performance

PUBLISHED
October 30 2015. Journal of Chromatography A. 2015 Oct 30; 1418:94-102. doi: 10.1016/j.chroma.2015.09.038.

AREA
Oncology

MEDIMMUNE AUTHORS
Steven T. Evans, Gisela Ferreira, David Robbins



A monoclonal antibody to ADAM17 inhibits tumor growth by inhibiting EGFR and non-EGFR mediated pathways

PUBLISHED
July 2015: Molecular Cancer Therapeutics. 2015 Jul; 14(7):1637-1649. doi: 10.1158/1535-7163.MCT-14-1040.

AREA
Oncology

MEDIMMUNE AUTHORS
Jonathan Rios-Doria, Darrin Sabol, Jon Chesebrough, Dave Stewart, Linda Xu, Ravinder Tammali, Li Cheng, Qun Du, Keven Schifferli, Ray Rothstein, Ching Ching Leow, Jenny Heidbrink-Thompson, Xiaofang Jin, Changshou Gao, Melissa Damschroder, Andrew Pierce, Robert E. Hollingsworth, David Tice, Emil Michelotti



Doxil synergizes with cancer immunotherapies to enhance anti-tumor responses in syngeneic mouse models

PUBLISHED
Aug 2015: Neoplasia. 2015 Aug; 17(8):661-70. doi: 10.1016/j.neo.2015.08.004.

AREA
Oncology

MEDIMMUNE AUTHORS
Jonathan Rios-Doria, Leslie Wetzel, Raymond Rothstein, Jon Chesebrough, Wei Zhao, Robert Hollingsworth, Nicholas Durham, Nicholas Holoweckyj, Ching Ching Leow



Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

PUBLISHED
Published online 23 Jul 2015: Nat Commun. 2015 Jul 23; 6:7877. doi: 10.1038/ncomms8877.

AREA
Oncology

MEDIMMUNE AUTHORS
Jonathan J. Phillips, Daniel R. Higazi, David Lowe



Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes

PUBLISHED
Published online 3 Mar 2015: J Pharm Sci. 2015 May; 104(5):1601-09. doi: 10.1002/jps.24387.

AREA
Oncology

MEDIMMUNE AUTHORS
Rachael Lewus



Low-frequency coding variants at 6p22.2-6p21.31 and 20q11.21 are associated with lung cancer risk in Chinese populations

PUBLISHED
Published online 7 May 2015: Am J Hum Genet. 2015 May 7; 96(5):832-40. doi: 10.1016/j.ajhg.2015.03.009.

AREA
Oncology

MEDIMMUNE AUTHORS
Jiaqi Huang, Brandon W. Higgs, Yihong Yao



Antibody drug conjugates: safety and regulatory considerations

PUBLISHED
Published online 30 May 2015: AAPS J. 2015 Sep; 17(5):1055-64. doi: 10.1208/s12248-015-9790-0.

AREA
Oncology

MEDIMMUNE AUTHORS
Mary Jane Masson Hinrichs, Rakesh Dixit



Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies with implications for combined therapy in ovarian cancer

PUBLISHED
Published online 10 Feb 2015: Cancer Research. 2015 Apr 01; 75(7):1255-1264. doi:10.1158/0008-5472.CAN-14-1801

AREA
Oncology

MEDIMMUNE AUTHORS
Hailhong Zhong, Robert Hollingsworth



Functionalised micro-capillary film for the rapid atline analysis of IgG aggregates in a cell culture bioreactor

PUBLISHED
Published online 18 September 2015: Mabs. 2015 Sep 3; 7(5):812-819. doi: 10.1080/19420862.2015.1065365.

AREA
Oncology

MEDIMMUNE AUTHORS
David Gruber, Marchel Kuiper, Ray Field, Richard Turner


Research & Development


Both reversible self-association and structural changes underpin molecular viscoelasticity of mAb solutions

PUBLISHED
2016. Journal of Pharmaceutical Sciences. 2016 Dec; 105(12):3496-3506. doi: 10.1016/j.xphs.2016.08.020.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
R&D: Prasad Sarangapani , Justin Weaver , Arun Parupudi , Prakash Manikwar,  Steven  Bishop, Jai Pathak



Camelid VHH affinity ligands enable separation of closely related biopharmaceuticals

PUBLISHED
Published online 27 Sep 2016: Biotechnology Journal. doi: 10.1002/biot.201600357.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
R&D: Timothy Pabst, Michaela Wendeler, Xiangyang Wang, Alan Hunter



Role of receptor occupancy assays by flow cytometry in drug development

PUBLISHED
2016. Cytometry.Part B, Clinical Cytometry. 2016: 90(2):110-116. doi: 10.1002/cyto.b.21355.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
Translational: Meina Liang



High affinity recognition of a selected amino acid epitope within a protein by Cucurbit[8]uril complexation

PUBLISHED
2016. Angewandte Chemie (International ed.in English). 2016: 55(45):14000-14004. doi: 10.1002/anie.201606763. 

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
R&D: Silvia Sonzini , Raphael Gubeli, Christopher van der Walle, Peter Ravn, Andreas Herrmann, Oren Scherman



A new PK equivalence test for a bridging study

PUBLISHED
2016. Journal of Biopharmaceutical Statistics. 2016; 26(5):992-1002. doi: 10.1080/10543406.2016.1148712.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
Translational: Steven Novick,  Harry Yang



Interconversion of Peptide Mass Spectral Libraries Derivatized with iTRAQ or TMT Labels

PUBLISHED
2016 Sep. Journal of Proteome Research. 2016 Sep 2; 15(9):3180-3187. doi: 10.1021/acs.jproteome.6b00406.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
R&D: Deniz Baycin Hizal, Michael Bowen



Storage Conditions of Conjugated Reagents Can Impact Results of Immunogenicity Assays

PUBLISHED
Jul 2016. Journal of Immunology Research. 2016 Jul; 2016: 1485615. doi: 10.1155/2016/1485615.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
Translational: Robert Kubiak, Nancy Lee, Yuan Zhu, Surekha Krishnan, Varghese Abraham, Peter Akufongwe, Wendy White
R&D: William Franch, Sophia Levitskaya, Christopher Larkin



Effect of freezing on lyophilization process performance and drug product cake appearance

PUBLISHED
Apr 2016. Journal of Pharmaceutical Sciences. 2016 Apr; 105(4): 1427-1433. doi: 10.1016/j.xphs.2016.02.003.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
R&D: Reza Esfandiary, Shravan Gattu, John Stewart, Sajal Patel



A scale-down mimic for mapping the process performance of centrifugation, depth, and sterile filtration

PUBLISHED
Published online 1 Mar 2016: Biotechnology and Bioengineering. doi: 10.1002/bit.25967.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
Brian Kenty, Michael Mollet, Kenneth Hwang, Steven Rose, Jean Bender



Combining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies

PUBLISHED
April 2016. MAbs. 2016 Apr; 8(3):501-512. doi: 10.1080/19420862.2016.1145865.

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
Keith Rickert, Luba Grinberg, Robert Woods, Susan Wilson, Michael Bowen, Manuel Baca



Development of therapeutic antibodies to G protein-coupled receptors and ion channels:  opportunities, challenges and their therapeutic potential in respiratory diseases

PUBLISHED
Published online 3 May 2016: Pharmacology & Therapeutics. doi: 10.1016/j.pharmthera.2016.04.013.

AREA
R&D Research

MEDIMMUNE AUTHORS
Julie Douthwaite, Donna Finch, Tomas Mustelin, Trevor Wilkinson



Rapid identification of biotherapeutics with label-free Raman spectroscopy

PUBLISHED
April 2016. Analytical Chemistry. 2016 Apr 19; 88(8):4361-4368. doi: 10.1021/acs.analchem.5b04794.

AREA
R&D

MEDIMMUNE AUTHORS
R&D: Robert Strouse, James B McGivney, Christopher Larkin



Critical considerations for developing nucleic acid macromolecule based drug products

PUBLISHED
March 2016. Drug Discovery Today. 2016 Mar; 21(3):430-444. doi: 10.1016/j.drudis.2015.11.012.

AREA
R&D

MEDIMMUNE AUTHORS
R&D: Bilikallahalli  Muralidhara, Rinku Baid, Steve Bishop



Critical considerations for developing nucleic acid macromolecule based drug products

PUBLISHED
March 2016. Drug Discovery Today. 2016 Mar; 21(3):430-444. doi: 10.1016/j.drudis.2015.11.012.

AREA
R&D

MEDIMMUNE AUTHORS
R&D: Bilikallahalli  Muralidhara, Rinku Baid, Steve Bishop



Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals

PUBLISHED
Published online 1 Sep 2015: Cytometry.Part B, Clinical Cytometry. doi: 10.1002/cyto.b.21319.

AREA
R&D

MEDIMMUNE AUTHORS
Inna Vainshtein, Amy K. Schneider, Bo Sun, Martin Schwickart, Lorin K. Roskos,  Meina Liang



Adsorption equilibrium and kinetics of monomer-dimer monoclonal antibody mixtures on a cation exchange resin

PUBLISHED
July 2015: Journal of chromatography A. 2015 Jul; 1402:46-59. doi: 10.1016/j.chroma.2015.05.007.

AREA
R&D

MEDIMMUNE AUTHORS
Timothy M. Pabst, Alan K. Hunter, Xiangyang Wang



Insights into the influence of the cooling profile on the reconstitution times of lyophilized protein formulations

PUBLISHED
Published online 4 Aug 2015: Eur J Pharm Biopharm. 2015 Oct 1; 96:247-54. doi: 10.1016/j.ejpb.2015.07.029.

AREA
R&D

MEDIMMUNE AUTHORS
James G. Biddlecombe, Christopher F. van der Walle



Testing drug additivity based on monotherapies

PUBLISHED
Published online 12 May 2015: Pharm Stat. 2015 Jul; 14(4):332-40. doi: 10.1002/pst.1689.

AREA
R&D

MEDIMMUNE AUTHORS
Harry Yang, Wei Zhao



Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development

PUBLISHED
Published online 1 Jan 2015: Bioanalysis. 2015 Jan 1; 7(2):229-42. doi: 10.4155/bio.14.274.

AREA
R&D

MEDIMMUNE AUTHORS
Yuling Wu



Universal method for the determination of nonionic surfactant content in the presence of protein

PUBLISHED
Published online 3 Mar 2015: J Sep Sci. 2015 Apr; 38(8):1318-25. doi: 10.1002/jssc.201400766.

AREA
R&D

MEDIMMUNE AUTHORS
Susanna Bilbulian, Ratnesh Pandey, Ellen O’Connor, Jose Casas-Finet, Patricia W. Cash



Global and local conformation of human IgG antibody variants rationalises loss of thermodynamic stability

PUBLISHED
Published online 20 Oct 2015: Angewandte Chemie (International Ed. in English). doi:10.1002/anie.201507223

AREA
R&D (Early Development)

MEDIMMUNE AUTHORS
Matthew Edgeworth, David Lowe, Alistair Kippen, Daniel Higazi


Cardiovascular and Metabolic Disease


A pH-Induced Switch in Human Glucagon-like Peptide-1 Aggregation Kinetics

PUBLISHED

2016. Journal of the American Chemical Society. 2016 Dec 21; 138(50):16259-16265.
doi: 10.1021/jacs.6b05025.

AREA
CVMD

MEDIMMUNE AUTHORS

R&D: Shahid Uddin, Paul Varley, Steve Bishop, Ana  Gomes dos Santos



A hingeless Fc fusion system for site-specific cleavage by IdeS

PUBLISHED
2016 Aug-Sep. MAbs. 2016 Aug-Sep; 8(6):1118-1125. doi: 10.1080/19420862.2016.1186321.

AREA
CVMD

MEDIMMUNE AUTHORS

R&D: Shabazz Novarra, Luba Grinberg, Keith Rickert, Arnita Barnes, Susan Wilson, Manuel Baca



Robust anti-obesity and metabolic effects of a GLP-1/glucagon dual-agonist peptide in rodents and non-human primates

PUBLISHED
Published online 5 Jul 2016: Diabetes, Obesity & Metabolism. doi: 10.1111/dom.12735.

AREA
CVMD

MEDIMMUNE AUTHORS

R&D: Simon Henderson, Anish Konkar, David Hornigold, James Trevaskis, Ronald Jackson, Jacqueline Naylor, Alessandra Rossi,  Maria Bednarek, Nicholas Bhagroo, Hamid Salari, Sarah Will, Stephanie Oldham, Joseph Grimsby, Shaun Maguire, Lutz Jermutus, Cristina Rondinone, Matthew Coghlan AZ: Maria Fritsch-Fredin, Rasmus Jansson-Löfmark



Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

PUBLISHED
December 2015: Best Practice & Research. Clinical Endocrinology & Metabolism. 2015 Dec; 29(6):821-831. doi: 10.1016/j.beem.2015.09.006.

AREA
CVMD

MEDIMMUNE AUTHORS
Arun Sharma



Insights From Cardiovascular Outcome Trials with Novel Antidiabetes Agents: What Have We Learned? An Industry Perspective

PUBLISHED
November 2015. Current Diabetes Reports. 2015 Nov; 15(11):87. doi: 10.1007/s11892-015-0663-9..

AREA
CVMD

MEDIMMUNE AUTHORS
Boaz Hirshberg



Structural and functional characterisation of a specific antidote for ticagrelor

PUBLISHED
Published online 28 May 2015: Blood. 2015 May 28; 125(22):3484-90. doi: 10.1182/blood-2015-01-622928.

AREA
CVMD

MEDIMMUNE AUTHORS
Andrew Buchanan, Philip Newton, Feenagh Keyes, Mark Austin, Jennifer Spooner, Mark Penney, Tristan Vaughan



BMP4 and BMP antagonists regulate human white and beige adipogenesis

PUBLISHED
Published online 201 Jan 2015: Diabeters. 2015 May; 64(5):1670-1681. doi: 10.2337/db14-1127.

AREA
CVMD

MEDIMMUNE AUTHORS
Joseph Grimsby, Cristina Rondinone